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MK-4827 (Niraparib)
MK-4827 (Niraparib) is an inhibitor of PARP 1 and 2 with IC50 = 3.8 and 2.1 nM, respectively, currently in clinical trials. In a whole cell assay, it inhibited PARP activity with EC50 = 4 nM and inhibited proliferation of cancer cells with mutant BRCA-1 and BRCA-2 with CC50 in the 10-100 nM range. MK-4827 was well tolerated in vivo and demonstrated efficacy as a single agent in a xenograft model of BRCA-1 deficient cancer.
Catalog NO: CT-MK4827
Synonym: Niraparib
CAS NO: 1038915-64-8
Mol. Formula: C19H20N4O ∙ HCl
MW: 356.9 (refer to certificate of analysis, batch-specific)
** in vivo Quality material. >99.5% by Achiral and Chiral HPLCs (attached). Water soluble (50 mM). HCl Salt, validated by a spot-on Elemental Analysis. Bulk stock. Same Day shipping.