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Skip Navigation LinksHome > Kinase Inhibitors > WEE1 > MK-1775 (Adavosertib) (AZD1775)
MK-1775 (Adavosertib) (AZD1775)
MK-1775 (Adavosertib) (AZD1775) is an orally bioavailable, clinical stage, small molecule inhibitor of Wee1, a kinase that phosphorylates CDC2 to inactivate the CDC2/cyclin B complex (regulating the G2 checkpoint). Since most human cancers harbor p53-dependent G1 checkpoint abnormalities, they are dependent on the G2 checkpoint. G2 checkpoint abrogation may therefore sensitize p53 deficient tumor cells to anti-cancer agents.
Catalog NO: CT-MK1775
Synonym: Adavosertib, AZD1775
CAS NO: 955365-80-7
Mol. Formula: C27H32N8O2
MW: 500.6 (refer to Certificate of Analysis, batch-specific)
** in vivo grade material. >99.5% by HPLC (attached), a recrystallized yellow powder, clean and impeccable. Monohydrate, validated by a spot-on Quantitative Microanalysis. Bulk Stock!! Same day shipping.