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Nedisertib
M-3814 (Nedisertib) (Peposertib) is an orally available, highly potent and selective inhibitor of DNA-dependent protein kinase (DNA-PK). It targets tumor cell growth and survival by inhibiting a critical Double-Strand Breaks (DSB) DNA damage repair mechanism. M3814 sensitizes multiple tumor cell lines to radiation therapy in vitro, and strongly potentiates the antitumor activity of ionizing radiation (IR) in vivo (Xenotransplanted Tumors in Nude Mice) (ref 1) with complete tumor regression applying a clinically relevant fractionated radiation regimen.
Catalog NO: CT-M3814
Synonym: M3814, M-3814, Peposertib
CAS NO: 1637542-33-6
Mol. Formula: C24H21ClFN5O3
MW: 481.9
** in vivo Quality Material. 99.5% by Achiral and Chiral HPLCs (attached). A pale-yellow Recrystallized powder. Anhydrous, validated by a spot-on Quantitative Elemental Analysis. Bulk stock (Discounted price offer for 0.5G, 1G, …,). Same day shipping.