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M-3258 is an orally-bioavailable potent and selective inhibitor of the immunoproteasome subunit LMP7 demonstrating >500-fold selectivity against β1c, β2c, β5c, β1i and β2i. M3258 displayed favorable pharmacokinetics and demonstrated strong LMP7 inhibition and anti-tumor activity in several multiple myeloma xenografts, including models that were refractory to Bortezomib.
Catalog NO: CT-M3258
Synonym: M3258
CAS NO: 2285330-15-4
Mol. Formula: C17H20BNO5
MW: 329.2
** **in vivo Quality Material. >99% by Achiral and Chiral HPLCs, white powder, with a quantitative elemental analysis. Bulk stock, same day shipping.