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LY-3295668 (AK-01)
LY3295668 (LY-3295668, AK-01) is an orally available, potent and highly selective Aurora A kinase (AurA) inhibitor with Ki of 0.8 nM, and H446 AurA auto-P IC50 of 0.6 nM, highly selective (>1000 fold) over Aurora B. LY3295668 is cytotoxic to RB1 mutant cancer cells (NCI-H446 cell IC50 = 0.752 uM), and achieves durable regression of RB1mut tumor xenografts.
Catalog NO: CT-LY3295
Synonym: AK-01, LY3295668
CAS NO: 1919888-06-4
Mol. Formula: C24H26ClF2N5O2 • 0.2H2O
MW: 493.6
** in vivo Quality Material. 99.5% pure by Achiral and Chiral HPLCs; 1/5 hydrate, validated by a spot-on quantitative elemental analysis. Bulk Stock. Prompt.