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LOXO-292 (Selpercatinib)
Selpercatinib (LOXO-292) is an orally available, potent and highly selective RET (Rearranged during Transfection) inhibitor, with IC50 values of 14.0 nM, 24.1 nM, and 530.7 nM for RET (WT), RET (V804M) , and RET (G810R), respectively. Displays robust in vitro and in vivo efficacies against cancers harboring abnormalities in RET kinase.
Catalog NO: CT-LX292
Synonym: Selpercatinib, ARRY-192
CAS NO: 2152628-33-4
Mol. Formula: C29H31N7O3 • 0.2H2O
MW: 529.2
** in vivo Quality Material. 99.9% Pure, a recrystallized white powder, with a spot-on Quantitative Elemental Analysis. Bulk (Grams). Prompt.