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LOXO-101 (Larotrectinib)
LOXO-101 (Larotrectinib) is an oral, potent and selective ATP-competitive pan-TRK inhibitor, with sub-nanomolar potency in IC50 values for all three TRK family members (TrkA, TrkB and TrkC), and >100-fold selectivity over other kinases. Displays robust in vitro and in vivo antitumor activities. It is currently in clinical evaluation.
Catalog NO: CT-LX101
Synonym: Larotrectinib, ARRY-470
CAS NO: 1223403-58-4
Mol. Formula: C21H22F2N6O2∙1/2H2O
MW: 437.4
** in vivo grade material. A single isomer (out of possible four), 99.9% chemical and stereomerical purity by achiral and chiral HPLCs (All QC docs attached), hemihydrate (by a spot-on microanalysis). Bulk Stock. Same day shipping.