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LHC-165 is an agonist (activator) of Toll-like Receptor 7 (TLR7), and an immuno-oncology modulator. TLR7 is a protein in the immune system that surveys and recognizes pathological malignance, and triggers the immune response by releasing infection-clearing cytokines if activated. It has demonstrated in mice that LHC-165 induced immune response, and reduced tumor growth, also showed signs of an abscopal effect. It is currently under evaluation in patients with advanced malignancies, either as a single agent or in combination with checkpoint inhibitor.
Catalog NO: CT-LHC165
Synonym: LHC165
CAS NO: 1258595-14-0
Mol. Formula: C29H32F2N3O7P
MW: 603.6 (refer to the Certificate of Analysis, batch-specific)
** in vivo Quality Material. >99.5% by HPLC. Clean, with a spot-on Quantitative Elemental Analysis, made for in vivo studies. Bulk, Prompt.