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LGX818 (Encorafenib)
Encorafenib (LGX818) is a selective ATP-competitive RAF kinase inhibitor of B-RafV600E mutant melanoma cell proliferation (EC50 = 4 nM) with little activity against wild-type B-Raf or a panel of 100 other kinases (IC50s = 900 nM). At oral doses of 6 mg/kg in human melanoma xenograft models, Encorafenib was shown to decrease phosphorylation of the B-Raf substrate MEK.
Catalog NO: CT-LGX818
Synonym: Encorafenib, NVP-LGX818
CAS NO: 1269440-17-6
Mol. Formula: C22H27ClFN7O4S
MW: 540.0
** in vivo Grade Material. >99.5% Pure by achiral and chiral HPLCs, with a spot-on quantitative elemental analysis. Bulk (Grams). Prompt.