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Home > Kinase Inhibitors > EGFR Mutants > Lazertinib

Lazertinib

Lazertinib is an oral, third-generation, brain-penetrant irreversible inhibitor of mutant EGFRs (ref 1), highly selective for mutant EGFRs (IC₅₀s = 1.7, 2, and 3.3 nM for EGFR^L858R/T790M, EGFR^Del19/T790M, and EGFR^Del19, respectively) over wild-type EGFR, HER2, and HER4 (IC₅₀s = 76, 364, and 1017 nM, respectively) (ref 1).

Catalog NO:	CT-LAZER
Synonym:	YH-25448, GNS-1480
CAS NO:	1903008-80-9
Mol. Formula:	C30H34N8O3
MW:	554.6

** in vivo Quality material. >99% Pure by HPLC. Anhydrous, validated with a spot-on Quantitative Elemental Analysis. Bulk stock (discounted price for 1G, 2G, 5G, …,). Same day shipping.

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NO	Size	Price	In Stock	Quantity
1	10 mg	$80.00	YES
2	50 mg	$240.00	YES
3	200 mg	$660.00	YES

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Solubility : refer to Certificate of Analysis

Storage : refer to Certificate of Analysis

Purity : >99% by HPLC

Original QC Data : HPLC, NMR, and Quantitative Elemental Analysis Report

There is no COA file for this product

1. J. Yun, et al. YH25448, an irreversible EGFR-TKI with potent intracranial activity in EGFR mutant non–small cell lung cancer. Clin. Cancer Res. 25(8), 2575-2587 (2019).

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