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KPT-330 (Selinexor)
KPT-330 is a first-in-class oral selective inhibitor of nuclear export proteins, inhibiting its nuclear export function by covalently binding to Cys528 in the nuclear export signal-binding groove of CRM1 (exportin 1). It demonstrates potent anticancer activity, inducing apoptosis in various leukemia and multiple myeloma cell lines (IC50s = 34-203 nM) and mouse models. It is currently being evaluated in several phase I and phase II clinical trials in both solid and hematological malignancies (refs 1-3).
Catalog NO: CT-KPT330
Synonym: Selinexor
CAS NO: 1393477-72-9
Mol. Formula: C17H11F6N7O
MW: 443.4
** A snow-white powder (picture attached), recrystallized. Clean (>99.8% by HPLC, Cis isomer, the active isomer) with a spot-on quantitative microanalysis. Made for in vivo studies. Bulk stock! Same day shipping.