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JQ1, (+)
(+)-JQ1 (Prod No. CT-JQ1) is a high affinity BET bromodomain (BRD) ligand binding selectively and competitively to the acetyl-lysine recognition pocket of BET bromodomain of Brd4 (Bromodomain-containing 4), displacing BET proteins from chromatin. Enantiomerically pure (optically pure) (+)-JQ1 binds to BRD4 bromodomains 1 and 2 with Kd values of ~50 and 90 nM, respectively, whereas the (−)-JQ1 enantiomer (wrong isomer) (mirror image of (+)-JQ1) has no appreciable affinity to BET bromodomains. JQ1 has been used as a chemical probe to investigate the role of BET bromodomains in the transcriptional regulation of oncogenesis.
Catalog NO: CT-JQ1
CAS NO: 1268524-70-4
Mol. Formula: C23H25ClN4O2S ∙ 0.2H2O
MW: 460.6
** in vivo grade material. Optically Pure. >99.5% by achiral and chiral HPLCs. A recrystallized snow-white powder, with quantitative elemental analysis. Bulk stock! Ship within 1 day.