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Home > Epigenetics Resch Products > BET Family Protein Inhibitors > JQ1, (+)

JQ1, (+)

(+)-JQ1 (Prod No. CT-JQ1) is a high affinity BET bromodomain (BRD) ligand binding selectively and competitively to the acetyl-lysine recognition pocket of BET bromodomain of Brd4 (Bromodomain-containing 4), displacing BET proteins from chromatin. Enantiomerically pure (optically pure) (+)-JQ1 binds to BRD4 bromodomains 1 and 2 with Kd values of ~50 and 90 nM, respectively, whereas the (−)-JQ1 enantiomer (wrong isomer) (mirror image of (+)-JQ1) has no appreciable affinity to BET bromodomains. JQ1 has been used as a chemical probe to investigate the role of BET bromodomains in the transcriptional regulation of oncogenesis.

Catalog NO:	CT-JQ1
Synonym:
CAS NO:	1268524-70-4
Mol. Formula:	C23H25ClN4O2S ∙ 0.2H2O
MW:	460.6

** in vivo grade material. Optically Pure. >99.5% by achiral and chiral HPLCs. A recrystallized snow-white powder, with quantitative elemental analysis. Bulk stock! Ship within 1 day.

Pricing and OrderingTechnical Data

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NO	Size	Price	In Stock	Quantity
1	2 x 5 mg	$80.00	YES
2	50 mg	$175.00	YES
3	100 mg	$275.00	YES
4	200 mg	$450.00	YES

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Solubility : Soluble in DMSO

Storage : See COA

Purity : >99.5% Chem and Optical Purity by HPLC and Chiral HPLC

Original QC Data : HPLC-MS, NMR, Chiral HPLC and Quantitative Elemental Analysis

Please Pick Batch NO:

CHEMIETEK, JQ1, Lot 02, NMR.pdf
CHEMIETEK, JQ1, Lot 02, HPLC-MS, Chiral HPLC.pdf
JQ1, chiral, Lot 02, Certificate of Analysis.pdf
JQ1, Chiral, Lot 02, Appearance (color).pdf

1.

2.

3. In contrast to yellow color from other vendors.

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