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JNJ-64619178 (JNJ64619178)
JNJ-64619178 (Onametostat) is a clinical-stage SAM-pocket binding (SAM Competitive) PRMT5 inhibitor with high selectivity and potency (PRMT5-MEP-50 IC50=0.14 nM) under different in vitro and cellular conditions. Demonstrates tumor regression in a biomarker-driven human small cell lung cancer xenograft model (NCI-H1048) and prolongs tumor growth inhibition after dosing cessation.
Catalog NO: CT-JNJ646
Synonym: Onametostat, JNJ64619178
CAS NO: 2086772-26-9
Mol. Formula: C22H23BrN6O2
MW: 483.4 (refer to Certificate of Analysis, batch-specific)
** in vivo Quality Material. 99.5-100% purity by achiral and chiral HPLCs (attached). Authenticated Stereo-Structure by 2D NMR. White (Not yellow) Powder. Bulk (get quote for larger sizes), same day shipping.