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Skip Navigation LinksHome > Neuroactive Research Products > Neuroactive/BBB Penetrant > J-147
J-147
J 147 is a potent neuroprotective and neurotrophic compound that protects against neurotoxicity in cortical neurons in vitro (EC₅₀ = 25 - 200 nM). Reduces soluble Aβ40 and Aβ42 levels and increases BDNF levels in the hippocampus in vivo. J 147 has been shown to enhance memory in normal animals and to prevent memory deficits in an Alzheimer’s disease mouse model. These effects are associated with an increase in brain derived neurotrophic factor levels, enhanced long-term potentiation, preservation of synaptic proteins, a reduction of markers for oxidative stress and inflammation, a reduction of amyloid plaques, and lower levels of soluble amyloid β.
Catalog NO: CT-J147
Synonym: CP-J147
CAS NO: 1146963-51-0
Mol. Formula: C18H17F3N2O2 ∙ 0.2H2O
MW: 354.0
** >99.5 pure (HPLC at 214 and 254 nm), + Clean NMR + A perfect Quantitative Elemental Analysis. Grams in stock from Indianapolis USA. Ship within 1 day.
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