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IACS-13909 (BBP-398) is a potent and specific allosteric inhibitor of SHP2, suppressing the signaling of RTK/MAPK pathway. IACS-13909 potently impedes the proliferation of tumors with a broad spectrum of RTKs as the oncogenic driver. Importantly, in NSCLC models with acquired resistance to Osimertinib, IACS-13909 administered as a single agent or in combination with Osimertinib potently reduces tumor cell proliferation in vitro and in vivo, which provide preclinical evidence for using a SHP2 inhibitor as a therapeutic strategy in acquired EGFR inhibitor-resistant NSCLC (ref 1).
Catalog NO: CT-IACS909
Synonym: BBP-398
CAS NO: 2160546-07-4
Mol. Formula: C17H18Cl2N6 (refer to the Certificate of Analysis, batch-specific)
MW: 377.3
** >99.5% Pure, in vivo grade material. A recrystallized yellow powder. HCl (hydrochloride) salt, with quantitative elemental analysis. Bulk Stock!! Same Day Shipping.