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Home > Kinase Inhibitors > Erk (Extracellular signal regulated kinase) > Hypothemycin

Hypothemycin

A resorcylic acid lactone polyketide. It is a kinase inhibitor targeting mitogen-activated protein (MAP) kinase pathways at four levels: mitogen receptors, MAP kinase kinase (MEK)1/2 and ERK1/2, and certain downstream ERK substrates.

Catalog NO:	CT-HPTM
Synonym:
CAS NO:	76958-67-3
Mol. Formula:	C₁₉H₂₂O₈
MW:	378.4

** A recrystallized, white crystalline powder/flakes (see attached picture). In stock from Indianapolis USA. Ship within 1 day.

Pricing and OrderingTechnical Data

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NO	Size	Price	In Stock	Quantity
1	1 mg	$175.00	YES
2	5 mg	$480.00	YES
3	10 mg	$800.00	YES

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Solubility : Soluble in DMSO, Acetone, Alcohols. Insoluble in water

Storage : Store at 0 °C (short term), -20 °C (long term), desiccated

Purity : >96% (HPLC)

Original QC Data : ¹³C, ¹H-NMR, MS and HPLC

Please Pick Batch NO:

Hypothemycin, Lot HPM-01A, Certificate of Analysis.pdf
Hypothemycin, Lot HPM-01A, Visual Appearance.pdf

1. Andreas Schirmer, et al, "Targeted covalent inactivation of protein kinases by resorcylic acid lactone polyketides", Proc. Natl. Acad. Sci. USA 2006 103 (11):4234-4239.

2. N. Winssinger, et al, Chemistry and biology of resorcylic acid lactones, Chem. Commun. (Camb). 1, 22, 2007.

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