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GSK-923295 is a first-in-class high affinity antimitotic inhibitor of centromere-associated protein E (CENP-E), potently and allosterically inhibiting CENP-E ATPase activity with a Ki value of 3.2 nM (Ref. 1). Display a broad-spectrum antiproliferative activity against a range of human tumor xenografts grown in nude mice, including models of colon, breast, ovarian, lung and other tumors. It is currently in clinical evaluations.
Catalog NO: CT-GSK923
Synonym: GSK-923295
CAS NO: 1088965-37-0
Mol. Formula: C32H38ClN5O4
MW: 592.1
** in vivo Quality material. >99% Pure by Achiral and Chiral HPLCs (Attached). Bulk stock. Same Day Shipping.