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GSK3685032 is a potent first-in-class DNMT1-selective inhibitor. Induces robust loss of DNA methylation, transcriptional activation and cancer cell growth inhibition in vitro. Displays a much-improved in vivo tolerability and greater DNA hypomethylation compared with decitabine, translating into superior tumor regression and survival mouse models of acute myeloid leukemia (ref 1).
Catalog NO: CT-GSK368
Synonym: GSK-3685032
CAS NO: 2170137-61-6
Mol. Formula: C22H24N6OS
MW: 420.5 (or refer to Certificate of Analysis, batch-specific)
** in vivo Quality Material. 99.9% by achiral and chiral HPLCs (attached). An optically pure single isomer (R-isomer), same as reported (ref 1). Bulk Stock (Get quote for 1, 2G, …,). Same Day Shipping.