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GSK2982772 is an oral, potent and selective RIP1 (Receptor Interacting Protein 1) Kinase inhibitor, a First-in-class to enter clinical trials for psoriasis, rheumatoid arthritis, and ulcerative colitis. It potently binds to RIP1 with exquisite kinase specificity (IC50 value of 1.0 nM; ADP-Glo activity assay) and has excellent activity in blocking many TNF-dependent cellular responses (IC50 value of 6.3 nM; human monocytic U937 cellular assay). It was also able to reduce spontaneous production of cytokines from human ulcerative colitis explants.
Catalog NO: CT-GSK298
Synonym: GSK-2982772
CAS NO: 1622848-92-3
Mol. Formula: C20H19N5O3∙0.2H2O
MW: 381.0
** The Optically Pure Source. in vivo Quality Material, >99.5% by Achiral and Chiral HPLCs. Textbook Quality (QC Docs attached), Bulk Stock (Get discounted quote for larger qty). Prompt.