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GSK2256098 is an orally bioavailable small molecule inhibitor of Focal adhesion kinase (FAK) (Ezymatic apparent Ki = 0.4 nM) , targeting specifically at phosphorylation site of the enzyme, tyrosine (Y) 397 (FAK Y397). GSK2256098 inhibition of FAK Y397 phosphorylation correlated with decreased levels of phosphorylated Akt and ERK in L3.6P1 cells (Cellular IC50 = 2-15 nM) , decreased cell viability, anchorage-independent growth, and motility in a dose dependent manner. (ref. 1-3). It is currently in clinical evaluation for cancer treatment.
Catalog NO: CT-GSK225
Synonym: GTPL7939
CAS NO: 1224887-10-8
Mol. Formula: C20H23ClN6O2 • 1/2H2O
MW: 423.9
** 99.9% Pure. InVivoGrade. A milk-white crystalline powder (picture attached). Hemihydrate. Clean & impeccable (see attached QC Docs. what you see is what you get). Bulk stock! Same day shipping.