GS-9688 (Selgantolimod) - Chemietek

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Home > Toll-like Receptor Modulators > GS-9688 (Selgantolimod)

GS-9688 (Selgantolimod)

Selgantolimod (GS-9688) is an orally active and selective toll-like receptor 8 (TLR8) agonist with potent TLR8 agonism (IL-12p40 EC50 = 220 nM) and >100-fold selectivity over TLR7 (IFN-α EC50 > 50 μM) in human peripheral blood mononuclear cells (PBMCs) (ref. 1). It is in the clinical evaluation for the treatment of hepatitis B virus (HBV) and human immunodeficiency virus (HIV) infection.

Catalog NO:	CT-GS9688
Synonym:	Selgantolimod
CAS NO:	2004677-13-6
Mol. Formula:	C14H20FN5O
MW:	293.3

** >99% Pure by Achiral and Chiral HPLCs (attached). Bulk stock (Discounted price for 0.1, 0.5G, …). Same Day Shipping.

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NO	Size	Price	In Stock	Quantity
1	5 mg	$250.00	YES
2	10 mg	$400.00	YES

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Solubility : Refer to Certificate of Analysis

Storage : Refer to Certificate of Analysis

Purity : 99% by Achiral and Chiral HPLCs

Original QC Data : Achiral and Chiral HPLCs, NMR, and Quantitative Elemental Analysis Report

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GS-9688 (Selgantolimod) Lot 01 Certificate of Analysis.pdf
C_K, GS-9688, Lot 01, Achiral HPLC.pdf
C_K, GS-9688, Lot 01, Chiral HPLC.pdf

1. R. L. Mackman, et al, Discovery of GS-9688 (Selgantolimod) as a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B, J. Med. Chem. 2020, 63, 18, 10188–10203

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