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GS-4997 (Selonsertib)
GS-4997 (Selonsertib), a clinical stage, orally bioavailable small molecule, is an inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. GS-4997 targets and binds to the catalytic kinase domain of ASK1 in an ATP-competitive manner, thereby preventing its phosphorylation and activation. GS-4997 prevents the production of inflammatory cytokines, down-regulates the expression of genes involved in fibrosis, suppresses excessive apoptosis and inhibits cellular proliferation.
Catalog NO: CT-G4997
Synonym: Selonsertib
CAS NO: 1448428-04-3
Mol. Formula: C24H24FN7O
MW: 445.5 (or refer to Certificate of Analysis, batch-specific)
** in vivo grade material. A snow-white powder (pic attached), 99.5% pure by HPLC, coming with a high-precision quantitative elemental analysis. Bulk stock. Prompt.