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GNE-7915
GNE-7915 is a Blood-Brain Barrier (BBB) penetrablesmall molecule inhibitor of Leucine-Rich Repeat Kinase 2 (LRRK2). It potently (Ki = 1 nM/ IC50 =9 nM (cell Assay)) and selectively (1 out of 187) inhibits the enzyme activity, and is CNS active, metabolically stable (refs 1-2).
Catalog NO: CT-GNE79
Synonym:
CAS NO: 1351761-44-8
Mol. Formula: C19H21F4N5O3
MW: 443.4
** in vivo grade material. >99.5% pure, white crystalline powder (pic attached), with a spot-on quantitative elemental analysis. Bulk stock. Ship within 1 day.