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Akt/(PKB (Protein Kinase B)
ALK (Anaplastic Lymphoma Kinase)
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ATM (Ataxia Telangiectasia Mutated Kinase)
ATR (Ataxia Telangiectasia and Rad3 Related)
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Aurora A Kinase Selective
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NIK (NF-κB-inducing kinase) Inhibitors
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PDK1
PI3K - p110 Alpha (α) Specific
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Wee1
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Monocarboxylate Transporter 1 (MCT 1) Inhibitor
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PLK (Polo-like kinase)
PLK1 (Polo-like Kinase 1) Selective
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RAF (Rapidly Accelerated Fibrosarcoma)
RET (Rearranged During Transfection) Kinase
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ROS1 (Proto-oncogene Tyrosine-protein Kinase ROS)
Syk (Spleen Tyrosine Kinase)
TGFβ (Transforming Growth Factor Beta (TGFβ) Receptor) Kinase
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TTK (Human Protein Kinase Monopolar Spindle 1 (hMps1))
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Wee1
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Mutant-IDH1 Inhibitor
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IMPDH (Inosine Monosphosphate Dehydrogenase) Inhibitor
IMPDH Inhibitor
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mTOR inhibitors
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RORγ (Retinoic Acid-related Orphan Receptor gamma (γ )) Agonist
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OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator
Monocarboxylate Transporter 1 (MCT 1) Inhibitor/Ligand
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MTH1 (NUDT1, Human MutT Homologue)
MTH1
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HCV Protease Inhibitor
HIV-1 integrase Inhibitor
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P-p68 (Phosphorylated-p68 RNA Helicase) Inhibitor
Thymidylate synthase inhibitor
OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator
PD-1/PD-L1 Checkpoint Inhibitors
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p53–MDM2 Interaction Inhibitor
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PDE4 ( Phosphodiesterase Type 4) Inhibitor/Modulators
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PTPN2/N1 (Protein Tyrosine Phosphatase Non-Receptor Type 2/1) Inhibitors
SHP2 Phosphatase Inhibitor
Wip1 Phosphatase Inhibitor
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Zinc Finger Protein (IKZF1/3) Degrader
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SHP2 Phosphatase Inhibitor
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GDC-1971
GDC-1971
Migoprotafib (GDC-1971) is an orally available, potent, and selective inhibitor of the protein tyrosine phosphatase SHP2, binding and stabilizing SHP2 in its inactive conformation.
Catalog NO:
CT-G1971
Synonym:
Migoprotafib, RLY-1971
CAS NO:
2377352-49-1
Mol. Formula:
C25H26N8O
MW:
454.5
** in vivo Quality material. >99% Pure by achiral and chiral HPLCs (Attached), with a spot-on Quantitative Elemental Analysis. Bulk stock (Discounted price on 0.5G, 1G, …). Same day shipping.
Pricing and Ordering
Technical Data
QC & Certificates
References
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Quantity
1
5 mg
$180.00
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10 mg
$250.00
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50 mg
$800.00
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100 mg
$1,300.00
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Solubility :
Refer to Certificate of Analysis
Storage :
Refer to Certificate of Analysis
Purity :
>99% by achiral and chiral HPLCs
Original QC Data :
Achiral and Chiral HPLCs, NMR, and Elemental Analysis Report
Please Pick Batch NO:
2
GDC-1971. Lot 02, Certificate of Analysis, .pdf
GDC-1971, Lot 02, Visual Appearance .pdf
1. Alexander M. Taylor, et al, Identification of GDC-1971 (RLY-1971), a SHP2 Inhibitor Designed for the Treatment of Solid Tumors, J. Med. Chem. 2023, 66, 19, 13384–13399
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