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GDC-0068 is a potent, APT-competitive and orally available small molecule pan-Akt inhibitor with IC50s of 5, 18 and 8 nM for Akt1, Akt2 and Akt3, respectively, and with selectivity over more than other 200 screened kinases. It displays robust antitumor activity with activated PI3K-Akt-mTOR pathway, and is currently in clinical trials.
Catalog NO: CT-G0068
Synonym: Ipatasertib, RG7440
CAS NO: 1001264-89-6
Mol. Formula: C24H32ClN5O2∙1.6HCl
MW: 520
** in vivo Quality Material. >99% Purity by Achiral and Chiral HPLCs. HCl salt, validated by Quantitative Elemental Analysis. Bulk, prompt.