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Kinase Inhibitors

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Activated Factor VII (Factor VIIa)

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Arginase Inhibitor

Adenosine Receptor Ligands

Autotaxin Inhibitor

Bcl-2 Protein Inhibitors/Degraders

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BCL-6 Protein Inhibitors

CD73 Immune Pathway Inhibitor/Modulator

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Cell Cycle Modulators

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Cell Metabolism Modulators

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CoREST-selective Deacetylase (CoreDAC) inhibitors

Degraders (Protein Degraders)

DNA Methyltransferase Inhibtors

DNA Repair Targeted Therapy

DNA/RNA Synthesis Inhibitor/Blocker

Endoplasmic Reticulum Stress Modulator (ERSM)

Epigenetics Resch Products

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Gamma (γ) Secretase (GS) Inhibitors

Glucocorticoid Receptor Antagonist/Modulator

Glutaminase Inhibitor

G-Protein-coupled Receptor Ligands

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Heat Shock Protein Research Products

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Hedgehog Signaling Pathway Modulators

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Hippo Pathway Signaling Inhibitor

HMG-CoA Reductase

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Hormone Receptor Modulators

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Hydrolase Inhibitors/Modulators

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IDO1 (INDOLEAMINE 2,3-DIOXYGENASE 1) Inhibitors

IDH (Isocitrate Dehydrogenase) Inhibitors

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IMPDH (Inosine Monosphosphate Dehydrogenase) Inhibitor

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Immune Activation Agents/Modulators

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Immuno/Inflammatory Mediators

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Immunoproteasome Inhibitor

Immuno-oncology Modulators

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Immunosuppressants/Immunochemotherapy Agents

Isomerase Inhibitor/Modulator

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Kinesin Ligand/Modulator

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KRAS Pathway Inhibitors

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Liver X receptor (LXR) Agonist/Modulator

Metabolic Pathway Modulators

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Monocarboxylate Transporter 1 (MCT 1) Inhibitor/Ligand

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Monocarboxylate Transporter 4 (MCT 4) Inhibitor

MTH1 (NUDT1, Human MutT Homologue)

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Neuroactive Research Products

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Notch/Wnt Signaling Pathway

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Nuclear Export Protein Inhibitors/Modulators

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Other Enzyme Inhibitors/Modulators

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OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator

PD-1/PD-L1 Checkpoint Inhibitors

p53–MDM2 Interaction Inhibitor/Modulator

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PCNA (Proliferating Cell Nuclear Antigen)

PDE4 ( Phosphodiesterase Type 4) Inhibitor/Modulators

Phosphatase Inhibitors/Modulators

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PLA2 (Phospholipase A2) Inhibitor

Polymerase Inhibitor/Modulator

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PPARG Agonist (Peroxisome Proliferator-activated Receptor Gamma Agomist)

Reagents for Biological Assays

RORγ (Retinoic Acid-related Orphan Receptor gamma (γ )) Agonist

SMAC Mimics and Inhibitors of IAP

Stem Cell Research Products

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STING (Stimulator of Interferon Genes) Agonist

SUMO Pathway Modulator

Toll-like Receptor Agonist

Ubiquitin / Proteasome System

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Wnt Signaling Pathway Modulators

YAP/TAZ Signaling Inhibitor

Zinc Finger Protein (IKZF1/3) Degrader

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Akt/(PKB (Protein Kinase B)

ALK (Anaplastic Lymphoma Kinase)

AMPK (AMP-Activated Protein Kinase)

ASK1 (Apoptosis Signal-regulating Kinase 1)

ATM (Ataxia Telangiectasia Mutated Kinase)

ATR (Ataxia Telangiectasia and Rad3 Related)

Aurora A Kinase Selective

Aurora B Kinase Selective

Aurora C Kinase Selective

AXL (AXL Receptor Tyrosine Kinase)

Bcr-Abl/c-kit/PDGFR/Src

BTK (Bruton's Tyrosine Kinase)

BUB1 (Budding Uninhibited by Benzimidazoles 1)(Mitotic checkpoint serine/threonine-protein kinase)

CDC7 (Cell Division Cycle 7-related Protein Kinase)

CDK (Cyclin-dependent Kinase)

CHK (Checkpoint Kinase)

CLK (CDC2-like-Kinase)

CLK2 (CDC2-like Kinase 2)

DDK (Dbf4-dependent kinase)

DNA-PK (DNA-Dependent Protein Kinase)

EphB4 (Ephrin Type-B Receptor 4) Kinase

Erk (Extracellular signal regulated kinase)

FAK (Focal Adhesion Kinase)

FGFR (Fibroblast Growth Factor Receptor)

FLT3 (Fms-like Tyrosine Kinase 3)

JAK (Janus Kinase)

JAK1/JAK2 Selective

Mps1 (Monopolar Spindle 1)

NIK (NF-κB-inducing kinase) Inhibitors

P21-Activated Kinases

P70S6K (Ribosomal Protein S6 Kinase)

PI3K - p110 Alpha (α) Specific

PI3K - p110 Beta (β) Specific

PI3K - p110 Delta (δ) Specific

PI3K - p110 Gamma (γ) Specific

PKC (Protein Kinase C)

PLK (Polo-like kinase)

PLK1 (Polo-like Kinase 1) Selective

PLK4 (Polo-like Kinase 4) Selective

RAF (Rapidly Accelerated Fibrosarcoma)

RET (Rearranged During Transfection) Kinase

RIP1 (Receptor Interacting Protein 1) Kinase

ROCK (Rho-Associated Protein Kinase)

ROS1 (Proto-oncogene Tyrosine-protein Kinase ROS)

Syk (Spleen Tyrosine Kinase)

TGFβ (Transforming Growth Factor Beta (TGFβ) Receptor) Kinase

TOPK (T–lymphokine-activated killer cell–originated protein kinase)

TRK (Tropomyosin Receptor Kinase) (Tyrosine Receptor Kinase)

TTK (Human Protein Kinase Monopolar Spindle 1 (hMps1))

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Factor VIIa inhibitor

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Bcl-2 Family Protein Inhibitors

BCL-2 Selective Inhibitors

BCL-XL Protein Degrader

BCL-XL Selective Inhibitors

MCL-1 Selective Inhibitors

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CD73 (ecto-5'-nucleotidase) Inhibitor

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BUB1 (Budding Uninhibited by Benzimidazoles 1)(Mitotic checkpoint serine/threonine-protein kinase)

CBP/β-catenin Modulators

Cell Cycle/DNA Damage

CDK Inhibitors/Modulators

CDC7 (Cell Division Cycle 7-related Protein Kinase)

CHK (Checkpoint Kinase)

CLK (CDC2-like-Kinase)

DNA Replication Modulators/Breakers

Endoplasmic Reticulum Stress Modulator (ERSM)

G-Quadruplex Ligand

IMPDH Inhibitor

Kinesin (CENP-E) Inhibitor

KRAS-G12C Inhibitors

KRASG12C (ON) (Tri-complex) Inhibitor

KRAS-G12D Inhibitors

KRAS-PDEδ Interaction Inhibitor

KRAS-SOS1 Inhibitors

Menin-MLL interaction inhibitors

Mps1 (Monopolar Spindle 1)

Notch Signaling Inhibitors

OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator/Inhibitor

p53-MDM2 Interaction Inhibitor

PCNA (Proliferating Cell Nuclear Antigen)

PRC2 (the catalytic subunit of polycomb repressive complex 2) >

PKMYT1 Kinase Inhibitor

SMAC Mimics and Inhibitors of IAP

TTK (Human Protein Kinase Monopolar Spindle 1 (hMps1))

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Monocarboxylate Transporter 1 (MCT 1) Inhibitor

Mutant Isocitrate Dehydrogenase-1 (IDH1) Inhibitor

Mutant Isocitrate Dehydrogenase-2 (IDH2) Inhibitor

OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator/Inhibitor

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Chemotherapy Agents

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ATPases (BRG1/BRM)

BET Family Protein Degraders

BET Family Protein Inhibitors

BET/Bromodomain (BDI and BDII) Selective Inhibitors

BET/BRD4 Degrader

BET/BRD9 Degrader

BET Bromodomain II (BDII) Selective Inhibitors

BET/Domain & Sub-set Selective Inhibitors

CBP/P300 Bromodomain Inhibitor

CoreDAC Inhibitors

DNMT1 (DNA Methyltransferase 1) inhibitor

DOT1L Methyltransferase Inhibitor

EP300/CBP HAT (Histone Acetyltransferases) Inhibitor

EZH1/2 Dual Inhibitors

EZH2 Methyltransferase Inhibitors

EZH2 (Mutant) METHYLTRANSFERASE INHIBITOR

HDAC (histone deacetylase) Inhibitors

HDAC1-Specific Inhibitors

HDAC3-Specific Inhibitors

HDAC6-Specific Inhibitors

Lysine specific demethylase 1 (LSD1) Inhibitor

Menin-MLL interaction inhibitors

PRC2 (the catalytic subunit of polycomb repressive complex 2)

PRMT5 (Protein Arginine Methyltransferase 5) Inhibitors/Modulators

PRMTs (Type I) Inhibitors/Modulators

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Adenosine Receptor Ligands

Angiotensin II receptor (AT1)

Endothelin receptor antagonist (type A specific)

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Heat Shock Proteins HSP90 Inhibitors

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Hedgehog Signaling Pathway Inhibitors

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HMG-CoA reductase inhibitor

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Androgen receptor

Glucocorticoid Receptor

RXRs (retinoid X receptors)

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Autotaxin Inhibitor

Caspase-1 Inhibitor

Cathepsin K Inhibitor

Neprilysin (MME) Inhibitor

PDE4 ( phosphodiesterase type 4)

PLA2 Inhibitors

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Mutant-IDH1 Inhibitor

Mutant-IDH2 Inhibitor

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IMPDH Inhibitor

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Liver X receptor (LXR) Agonist/Modulator

RORγ (Retinoic Acid-related Orphan Receptor gamma (γ )) Agonist

STING (STIMULATOR OF INTERFERON GENES) AGONIST

Toll-like Receptor Agonist

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Anti-angiogenesis

Anti-inflammatory

Arginase Inhibitor

Autotaxin Inhibitors

PLA2 Inhibitors

Prostanoid ligand

RIP1 (RECEPTOR INTERACTING PROTEIN 1) KINASE

TGFβ Kinase Inhibitor

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Adenosine 2A Receptor Antagonist

Arginase Inhibitor

CD73 (ecto-5'-nucleotidase) Inhibitor

CBP/β-catenin Modulators

CoreDAC Inhibitors

IDO1 (Indoleamine 2,3-dioxygenase 1) Inhibitor

IKZF1/3 (Zinc Finger Protein 1/3)

Immunoproteasome Inhibitor

Liver X receptor (LXR) Agonist/Modulator

mTOR inhibitors

PD-1/PD-L1 CHECKPOINT INHIBITORS

PI3Kγ (GAMMA) Specific Inhibitors

PTPN2/N1 (Protein Tyrosine Phosphatase Non-Receptor Type 2/1) Inhibitors

RORγ (Retinoic Acid-related Orphan Receptor gamma (γ )) Agonist

SHP2 Phosphatase Inhibitor

STING (Stimulator of Interferon Genes) Agonist

SUMOylation Inhibitor

TGFβ Kinase Inhibitor

Toll-like Receptor Agonist

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Topoisomerase I

Topoisomerase II

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Kinesin (CENP-E) Inhibitor

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G12C Mutant Inhibitors

G12D Mutant Inhibitors

KRAS-PDEδ Interaction Inhibitor

Pan-KRAS Inhibitors

SOS1 Inhibitors

Tri-complex KRASG12C (ON) Inhibitor

Tri-complex KRAS inhibitors

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Arginase Inhibitor

Glutaminase Inhibitor

IDH (Isocitrate Dehydrogenase) Inhibitors

IMPDH (Inosine Monosphosphate Dehydrogenase) Inhibitor

MAT2A Inhibitor

Monocarboxylate Transporter 1 (MCT 1) Inhibitor

Monocarboxylate Transporter 4 (MCT 4)

OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator

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Monocarboxylate Transporter 1 (MCT 1) Inhibitor

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Neuroactive/BBB Penetrant

Orexin Receptor Antagonists

SDAM (Serotonin-Dopamine Activity Modulator)

TRK (Tropomyosin Receptor Kinase)(Tyrosine Receptor Kinase) Inhibitor

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CBP/β-catenin Modulators

Gamma (γ) Secretase (GS) Inhibitors

Notch Signaling Inhibitors

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CRM1 (exportin 1) Inhibitor(s)

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HCV Protease Inhibitor

HIV-1 integrase Inhibitor

Oxidoreductase Inhibitor

P-p68 (Phosphorylated-p68 RNA Helicase) Inhibitor

Thymidylate synthase inhibitor

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p53–MDM2 Interaction Inhibitor

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PTPN2/N1 (Protein Tyrosine Phosphatase Non-Receptor Type 2/1) Inhibitors

SHP2 Phosphatase Inhibitor

Wip1 Phosphatase Inhibitor

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PARP (Poly (ADP-ribose) polymerase)

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Stem cell research

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NADD8-Activating Enzyme Inhibtor

Proteasome Inhibitor

SUMOylation Inhibitor

Ubiquitin-Activating Enzyme Inhibitor

USP1 (Ubiquitin Specific Protease 1)

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