EPZ-6438 (Tazemetostat) - Chemietek

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Home > Epigenetics Resch Products > EZH2 Methyltransferase Inhibitors > EPZ-6438 (Tazemetostat)

EPZ-6438 (Tazemetostat)

EPZ-6438 (Tazemetostat) is an orally bioactive, potent, selective and S-adenosyl methionine (SAM) competitive inhibitor of Histone Methyltransferase (HMT) EZH2 with a Ki = 2.5 nM for wild type EZH2. The compound potently inhibits all known mutants of EZH2 that have been identified in non-Hodgkin lymphoma (NHL) patient samples. It has greater than 4500-fold selectivity against other 14 HMTs tested and 35-fold selectivity against the closely related enzyme EZH1.

Catalog NO:	CT-EPZ438
Synonym:	Tazemetostat, EPZ6438
CAS NO:	1403254-99-8
Mol. Formula:	C₃₄H₄₄N₄O₄
MW:	572.7

** in vivo Quality Material. >99% Pure. Anhydrous, validated by a spot-on Elemental Analysis. Bulk stock (Discounted price for 1G, 2G, …). Same day shipping.

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NO	Size	Price	In Stock	Quantity
1	50 mg	$120.00	YES
2	200 mg	$360.00	YES

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Solubility : In DMSO

Storage : Store at 0°C (short term), -20°C (long term), desiccated

Purity : >99% (HPLC at 214 and 254 nm)

Original QC Data : HPLC, ¹HNMR, and Quantitative Elemental Analysis

Please Pick Batch NO:

EPZ6438, Lot 04, Certificate of Analysis.pdf
C_K, EPZ-6438, Lot 04, HPLC.PDF
C_K, EPZ-6438, Lot 04, NMR in DMSO.pdf

S. K. Knutson, et al., Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2. Proc Natl Acad Sci U S A. 2013 May 7, 110(19), 7922-7

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