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EPZ-6438 (Tazemetostat)
EPZ6438 (Tazemetostat, E7438) is an orally bioactive, potent, selective and S-adenosyl methionine (SAM) competitive inhibitor of Histone Methyltransferase (HMT) EZH2 with a Ki = 2.5 nM for wild type EZH2. The compound potently inhibits all known mutants of EZH2 that have been identified in non-Hodgkin lymphoma (NHL) patient samples. It has greater than 4500-fold selectivity against other 14 HMTs tested and 35-fold selectivity against the closely related enzyme EZH1.
Catalog NO: CT-EPZ438
Synonym: Tazemetostat, E7438
CAS NO: 1403254-99-8
Mol. Formula: C34H44N4O4 ∙ 0.4HCl
MW: 587.3
** 99.9%, in vivo Grade Material. White crystalline white powder (picture attached). Bulk stock. Ship within 1 day.