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Home > STING (Stimulator of Interferon Genes) Agonist > E-7766

E-7766

E-7766 (E7766) is a structurally novel class of macrocyclic molecule, metabolically stable, specific, and potent (Kd in lower nM, on par with that of the natural ligand 2′,3′-cGAMP (Prod No. CT-CGMAP) agonist for both human and mouse STING (Stimulator of Interferon Genes). Exhibits broad pan‐genotypic activity in all major human STING variants. Demonstrates potent antitumor activity with long lasting immune memory response in a mouse liver metastatic tumor model (ref. 1, 2).

Catalog NO:	CT-E7766
Synonym:	E7766
CAS NO:	2242635-02-3
Mol. Formula:	(C₂₄H₂₄ F₂N₁₀O₈S₂)^2- • 2(NH₄)⁺
MW:	780.7

** in vivo Quality Material. >99.5% by HPLC (attached), water-soluble, diammonium salt (clinical formulation format). Bulk (discounted price on sizes: 20, 50, 100, 200mg, …,). Same Day Shipping. 1.0 mg equals 1.28 µmol.

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NO	Size	Price	In Stock	Quantity
1	1 mg	$150.00	YES
2	5 mg	$490.00	YES
3	10 mg	$850.00	YES

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Solubility : Soluble in Water, >20mM

Storage : refer to Certificate of Analysis

Purity : >99% by HPLC

Original QC Data : HPLC-MS, NMR

Please Pick Batch NO:

E-7766, Lot 01, Certificate of Analysis.pdf
E-7766, Lot 01, Visual Appearance.pdf
C_K, E-7766, Lot 01, HPLC-MS.pdf
E-7766, Lot 01, NMR (HP).pdf

1. Kuan-Chun Huang, et al, Demonstration of E7766, a novel STING agonist, as a potent immunotherapy in BCG-insensitive non-muscle invasive bladder cancer models via intravesical administration [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl): Abstract nr 592.

2. Patent, US 2020/0299321 A1

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