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Home > KRAS Pathway Inhibitors > KRAS-PDEδ Interaction Inhibitor > Deltarasin HCl salt

Deltarasin HCl salt

Deltarasin is a novel small molecule inhibiting the KRAS-PDEδ interaction and thus impairing oncogenic KRAS signalling. Deltarasin selectively binds to the prenyl-binding pocket of PDEδ with nanomolar affinity (IC50 = 41 nM, binding to PDEδ in cell) [Ref 1].

Catalog NO:	CT-DELT
Synonym:
CAS NO:	1440898-82-7 (HCl salt) 1440898-61-2 (Free Base)
Mol. Formula:	C₄₀H₃₇N₅O∙3HCl∙3H₂O
MW:	767.2

** in vivo Quality Material. >99.5% Pure by Achiral HPLC and Chiral HPLCs, Hydrochloride, coming with a Quantitative Elemental Analysis. Water-soluble (50mM). Bulk, prompt from Indianapolis..

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NO	Size	Price	In Stock	Quantity
1	5 mg	$125.00	YES
2	10 mg	$170.00	YES
3	50 mg	$490.00	YES

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Solubility : Soluble in Water (38.4mg, 50 mM)

Storage : Store at 0°C (short term), -20°C (long term), desiccated

Purity : >99.5% chem and optical purity (HPLC and Chiral HPLC)

Original QC Data : HPLC-MS, ¹HNMR, Chiral HPLC, and Quantitative Elemental Analysis

Please Pick Batch NO:

Deltarasin Lot 01, Certificate of Analysis.pdf
C_K, Deltarasin, Lot 01, Achiral HPLC-MS.pdf
C_K, Deltarasin, Lot 01, Chiral HPLC.pdf
C_K, Deltarasin, Lot 01, NMR,.pdf

Ref 1. G. Zimmermann, et al., Small molecule inhibition of the KRAS–PDEδ interaction impairs oncogenic KRAS signalling, Nature 2013, 497 (7451), 638–642

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