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Skip Navigation LinksHome > Kinase Inhibitors > FAK (Focal Adhesion Kinase) > Defactinib (VS-6063, PF-04554878)
Defactinib (VS-6063, PF-04554878)
Focal adhesion kinase (FAK), a non-receptor tyrosine kinase , orchestrates cell signaling through integrins and growth factor receptors and plays important roles in tumorigenesis. Defactinib is a potent, selective, and orally active FAK inhibitor with demonstrated tolerability and preliminary clinical activity targeting cancer stem cells, working as a single agent as well as in combination with paclitaxel.
Catalog NO: CT-DEFA
Synonym: VS-6063, PF-04554878
CAS NO: 1073154-85-4
Mol. Formula: C20H21F3N8O3S ∙ 0.8HCl
MW: 539.7
** A white crystalline powder, re-crystallized (see attached picture), clean (99.5% by HPLC) + impeccable 1H-NMR, HCl salt (0.8 eq.), confirmed by Quantitative Elemental Analysis. Ship within 1 day.