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Dasatinib is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promoting activities of these kinases. Apparently because of its less stringent binding affinity for the BCR-ABL kinase, dasatinib has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations. SRC-family protein-tyrosine kinases interact with variety of cell-surface receptors and participate in intracellular signal transduction pathways; tumorigenic forms can occur through altered regulation or expression of the endogenous protein and by way of virally-encoded kinase genes. 
Catalog NO: CT-DS001
Synonym: Sprycel
CAS NO: 863127-77-9
Mol. Formula: C22H26ClN7O2S · H2O
MW: 506.02
** A white powder (picture attached), clean, offered as a monohydrate, manifested by a perfect quantitative elemental analysis. Bulk Stock. Ship within 1 day.