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Skip Navigation LinksHome > Kinase Inhibitors > ErbB > Dacomitinib
Dacomitinib (PF-00299804) is a second-generation irreversible pan-erbB receptor tyrosine kinase inhibitor currently in clinical trials. It is believed to irreversibly inhibit erbB tyrosine kinase activity through binding at the ATP site and covalent modification of nucleophilic cysteine residues in the catalytic domains of erbB family members
Catalog NO: CT-DACO
Synonym: PF-00299804
CAS NO: 1042385-75-0 (Hydrate) 1110813-31-4 (Anhydrous)
Mol. Formula: C24H25ClFN5O2 ∙ H2O
MW: 488
** In vivo grade material. Monohydrate, validated by a spot-on quantitative elemental analysis. Bulk. Prompt