CYT-387 (Momelotinib) - Chemietek

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Home > Kinase Inhibitors > JAK1/JAK2 Selective > CYT-387 (Momelotinib)

CYT-387 (Momelotinib)

CYT387 (Momelotinib) is an ATP-competitive small molecule potently inhibiting JAK1/JAK2 kinases (IC50 = 11 and 18 nM, respectively), with significantly less activity against JAK3 (IC50 = 155 nM).

Catalog NO:	CT-CYT387
Synonym:	Momelotinib, CYT387
CAS NO:	1056634-68-4
Mol. Formula:	C₂₃H₂₂N₆O₂
MW:	414.46

** in vivo Quality material. 99.5% by HPLC (Attached). Hemihydrate, validated by a spot-on Elemental Analysis. Bulk stock (Get quote for 1G, 2G, ...). Same day shipping.

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NO	Size	Price	In Stock	Quantity
1	10 mg	$120.00	YES
2	50 mg	$290.00	YES
3	100 mg	$440.00	YES
4	200 mg	$690.00	YES

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Solubility : Soluble in DMSO

Storage : Store at 0°C (short term), -20°C (long term), desiccated

Purity : >99.5% (HPLC at 220, 254 and 280 nM))

Original QC Data : HPLC-MS, ¹HNMR, and Quantitative Elemental Analysis

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Current Lot, Certificate of Analysis

1. Pardanani A, Lasho T, Smith G, Burns CJ, Fantino E, Tefferi A., CYT387, a selective JAK1/JAK2 inhibitor: in vitro assessment of kinase selectivity and preclinical studies using cell lines and primary cells from polycythemia vera patients, Leukemia. 2009 Aug; 23(8):1441-5.

2. Tyner JW, Bumm TG, Deininger J, Wood L, Aichberger KJ, Loriaux MM, Druker BJ, Burns CJ, Fantino E, Deininger MW. CYT387, a novel JAK2 inhibitor, induces hematologic responses and normalizes inflammatory cytokines in murine myeloproliferative neoplasms. Blood. 2010 Jun 24; 115(25):5232-40.

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