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Home > Kinase Inhibitors > Aurora Kinase > CYC-116

CYC-116

An orally-active inhibitor of Aurora kinases A and B, and VEGFR2, currently in clinical trial for cancer treatment.

Catalog NO:	CT-C116
Synonym:
CAS NO:	693228-63-6
Mol. Formula:	C₁₈H₂₀N₆OS
MW:	368.5

** Please ask for quote for other quantities, Grams in stock from Indianapolis USA.

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NO	Size	Price	In Stock	Quantity
1	10 mg	$110.00	YES
2	50 mg	$330.00	YES
3	100 mg	$500.00	YES

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Solubility : Soluble in DMSO and Ethanol

Storage : Store at 0°C (short term), -20°C (long term), desiccated

Purity : > 99% (HPLC)

Original QC Data : ¹HNMR, HPLC

There is no COA file for this product

1. Wang, Shudong; Midgley, Carol A.; Scaerou, Frederic; Grabarek, Joanna B.; Griffiths, Gary; Jackson, Wayne; Kontopidis, George; McClue, Steven J.; McInnes, Campbell; Meades, Christopher; Mezna, Mokdad; Plater, Andy; Stuart, Iain; Thomas, Mark P.; Wood, Gavin; Clarke, Rosemary G.; Blake, David G.; Zheleva, Daniella I.; Lane, David P.; Jackson, Robert C.; Glover, David M.; Fischer, Peter M. Discovery of N-Phenyl-4-(thiazol-5-yl)pyrimidin-2-amine Aurora Kinase Inhibitors. Journal of Medicinal Chemistry (2010), 53(11), 4367-4378.

2. MacCallum, David; Green, Simon. Combination of CNDAC with a 2-substituted-4-heteroaryl-pyrimidine amine and use thereof in the treatment of a proliferative disorder. PCT Int. Appl. (2007), 48pp. CODEN: PIXXD2 WO 2007132228 A1 20071122 CAN 147:534652 AN 2007:1333052

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