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Home > Kinase Inhibitors > FLT3 (Fms-like Tyrosine Kinase 3) > Crenolanib

Crenolanib

Crenolanib is an orally bioavailable, selective small molecule inhibitor of the Platelet-derived growth factor receptor (PDGFR) tyrosine kinase, inhibiting both purified PDGFRα and PDGFRβ with IC50s of 0.9 nM and 1.8 nM, respectively. It is also a type I pan-FLT3 inhibitor, highly selective over the closely related protein tyrosine kinase KIT, capable of inhibiting both FLT3/ITD and resistance-conferring FLT3/D835 mutants in vivo (Refs 2 & 3). It is considered to be an important next-generation FLT3 inhibitor.

Catalog NO:	CT-CREN
Synonym:	CP-868596
CAS NO:	670220-88-9
Mol. Formula:	C₂₆H₂₉N₅O₂
MW:	443.54

** in vivo Quality Material. 99.5% pure by HPLC (attached). Anhydrous, validated with a Quantitative Elemental Analysis. Bulk Stock (get discounted quote for 0.5G, 1G, 2G, …,). Same day shipping.

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NO	Size	Price	In Stock	Quantity
1	10 mg	$120.00	YES
2	50 mg	$360.00	YES
3	200 mg	$860.00	YES

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Solubility : Soluble in DMSO, and water with 1 eq. of acid

Storage : Store at 0°C (short term), -20°C (long term), desiccated

Purity : >99.5% (HPLC)

Original QC Data : HPLC-MS, ¹HNMR, and Quantitative Elemental Analysis

Please Pick Batch NO:

Crenolanib, Current, Certificate of Analysis
Crenolanib, Lot 01, Appearance (Color).pdf

1. M. C Heinrich, et al., Crenolanib inhibits the drug-resistant PDGFRA D842V mutation associated with imatinib-resistant gastrointestinal stromal tumors. Clin Cancer Res, 2012, Jun 27

2. C. C. Smith, et al, Crenolanib is a selective type I pan-FLT3 inhibitor, PNAS, April 8, 2014, Vol. 111, no. 14, 5319-5324

3. A. Galanis, et al, Crenolanib is a potent inhibitor of FLT3 with activity against resistance-conferring point mutants, Blood , 11/2013; DOI: 10.1182/blood-2013-10-529313

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