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Crenolanib is an orally bioavailable, selective small molecule inhibitor of the Platelet-derived growth factor receptor (PDGFR) tyrosine kinase, inhibiting both purified PDGFRα and PDGFRβ with IC50s of 0.9 nM and 1.8 nM, respectively. It is also a type I pan-FLT3 inhibitor, highly selective over the closely related protein tyrosine kinase KIT, capable of inhibiting both FLT3/ITD and resistance-conferring FLT3/D835 mutants in vivo (Refs 2 & 3). It is considered to be an important next-generation FLT3 inhibitor.
Catalog NO: CT-CREN
Synonym: CP-868596
CAS NO: 670220-88-9
Mol. Formula: C26H29N5O2
MW: 443.54
** A white to pale yellow recrystallized crystalline powder (see attached picture), >99.5% pure by HPLC, + a perfect Quantitative Elemental Analysis, made for in vivo studies. Bulk Stock! Same Day Shipping.