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CEP-37440 is a highly potent, selective and orally active inhibitor of ALK (Ezymatic IC50: 3.5 nM , Cellular IC50: 40 nM , Cellular IC50 in 75% human plasma: 120 nM) and FAK (Ezymatic IC50: 2.3 nM , Cellular IC50: 88 nM ), displaying a favorable pharmaceutical and pharmacokinetic profile and robust and selective pharmacologic efficacy against ALK /FAK mediated human cancer cells and tumor xenograft models in mice. It is currently in clinical trials.
Catalog NO: CT-CEP374
CAS NO: 1391712-60-9
Mol. Formula: C30H38ClN7O3∙1.3 HCl
MW: 627.5
** in vivo Quality material. >99.5% by achiral and chiral HPLCs (Attached), a single enantiomer (S-enantiomer, clinically active isomer by Chiral HPLC).* Bulk stock, ship within 1 day.