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CC-671
CC-671 is a potent and selective dual inhibitor of TTK (Human Protein Kinase Monopolar Spindle 1 (hMps1)) / CLK2 (CDC2-like Kinase), with IC50 values of 5 nM and 3 nM, respectively (ref 1), a unique feature targeting both TTK (mitotic exit) and CLK2 (mRNA splicing). It displays a strong single agent in vivo antitumor efficacy in multiple TNBC (Triple negative breast cancer) xenograft models (ref 1, 2). It is currently in IND-enabling studies as a single agent TNBC therapy.
Catalog NO: CT-CC671
Synonym:
CAS NO: 1618658-88-0
Mol. Formula: C28H28N6O4
MW: 512.6
** in vivo grade, white powder (picture attached), 99.5% pure. Bulk Stock (get discounted quote for larger sizes). Same day shipping.