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Home > Kinase Inhibitors > CLK2 (CDC2-like Kinase 2) > CC-671

CC-671

CC-671 is a potent and selective dual inhibitor of TTK (Human Protein Kinase Monopolar Spindle 1 (hMps1)) / CLK2 (CDC2-like Kinase), with IC50 values of 5 nM and 3 nM, respectively (ref 1), a unique feature targeting both TTK (mitotic exit) and CLK2 (mRNA splicing). It displays a strong single agent in vivo antitumor efficacy in multiple TNBC (Triple negative breast cancer) xenograft models (ref 1, 2). It is currently in IND-enabling studies as a single agent TNBC therapy.

Catalog NO:	CT-CC671
Synonym:
CAS NO:	1618658-88-0
Mol. Formula:	C28H28N6O4
MW:	512.6

** in vivo Quality Material. 99.5% pure, with Quantitative Elemental Analysis. Bulk Stock (get discounted quote for 0.5G, 1G, 2G, …,). Same day shipping.

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NO	Size	Price	In Stock	Quantity
1	5 mg	$100.00	YES
2	10 mg	$175.00	YES
3	50 mg	$495.00	YES

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Solubility : Refer to Certificate of Analysis

Storage : Refer to Certificate of Analysis

Purity : 99.5% purity by HPLC

Original QC Data : HPLC-MS, NMR, and Quantitative Elemental Analysis Report

Please Pick Batch NO:

CC-671. Lot 01, Certificate of Analysis.pdf
CC-671, Lot 01, Visual Appearance.pdf

1. Jennifer R. Riggs, et al, The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen, J. Med. Chem., 2017, 60 (21), pp 8989–9002

2. D. Zhu, et al, Synthetic lethal approach identifies potent and selective TTK and CLK inhibitor with preclinical anticancer activity in triple-negative breast cancer model: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2017 Oct 26-30; Philadelphia, PA. Philadelphia (PA): AACR; Mol Cancer Ther 2018;17(1 Suppl):Abstract No B177

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