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An epoxomicin derivate with potential antineoplastic activity. It irreversibly binds to and inhibits the chymotrypsin-like activity of the 20S proteasome, an enzyme responsible for degrading a large variety of cellular proteins. Inhibition of proteasome-mediated proteolysis results in an accumulation of polyubiquinated proteins, which may lead to cell cycle arrest, induction of apoptosis, and inhibition of tumor growth.
Catalog NO: CT-CARF
Synonym: PR-171
CAS NO: 868540-17-4
Mol. Formula: C40H57N5O7
MW: 719.91
** Snow white powder/flakes, with a perfect Quantitative Elemental Analysis. Ship within 1 day.