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Home > Kinase Inhibitors > c-Met > BPI-9016M

BPI-9016M

BPI-9016M is a potent, orally active, and selective tyrosine kinase inhibitor targeting both c-MET and AXL. It significantly suppressed tumor cell growth in lung adenocarcinoma PDX models, particularly in the tumors with high expression of c-Met (refs 1-3).

Catalog NO:	CT-BPI9016M
Synonym:	BPI9016M
CAS NO:	1528546-94-2
Mol. Formula:	C25H18F2N4O3
MW:	406.4 (Or refer to the Certificate of Analysis, batch-specific)

** in vivo Quality material. >99% Pure by HPLC (Attached). Hydrate, validated by a Quantitative Elemental Analysis. Bulk stock (Discounted price for 0.5, 1G, 2G,…,). Same Day Shipping.

Pricing and OrderingTechnical Data

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NO	Size	Price	In Stock	Quantity
1	10 mg	$160.00	YES
2	50 mg	$480.00	YES
3	100 mg	$760.00	YES

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Solubility : Refer to Certificate of Analysis

Storage : Refer to Certificate of Analysis

Purity : 99% by HPLC

Original QC Data : HPLC, MS, NMR, and Quantitative Elemental Analysis Report

Please Pick Batch NO:

BPI-9016M Lot 01 Certificate of Analysis.pdf
BPI-9016M Lot 01 Visual Appearance.pdf
C_K, BPI-9016M, Lot 01, HPLC.pdf

1. Hu X, et al. First-in-human phase I study of BPI-9016M, a dual MET/Axl inhibitor, in patients with non-small cell lung cancer.J Hematol Oncol. 2020 Jan 16;13(1):6

2. Zhang P, et al. BPI-9016M, a c-Met inhibitor, suppresses tumor cell growth, migration and invasion of lung adenocarcinoma via miR203-DKK1. Theranostics. 2018 Nov 12;8(21):5890-5902.

3. C. Jiang, et al, Radiosensitizing effect of c-Met kinase inhibitor BPI-9016M in esophageal squamous cell carcinoma cells in vitro and in vivo, Annals of Translational Medicine, Vol 9, No 24 (December 31, 2021)

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