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Skip Navigation LinksHome > Polymerase Inhibitor/Modulator > PARP (Poly (ADP-ribose) polymerase) > BMN-673 (Talazoparib) (MDV-3800) (LT 00673)
BMN-673 (Talazoparib) (MDV-3800) (LT 00673)
BMN-673 (Talazoparib) (MDV-3800) is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP), potently inhibiting PARP1 and PARP2 enzyme activity with Ki = 1.2 and 0.87 nM, respectively. It inhibits PARP-mediated PARylation in a whole-cell assay with an EC50 of 2.51 nM and prevents proliferation of cancer cells carrying mutant BRCA1/2, with EC50= 0.3 nM (MX-1) and 5 nM (Capan-1), respectively. Displays favorable pharmacokinetic (PK) properties and remarkable antitumor efficacy in the BRCA1 mutant MX-1 breast cancer xenograft model following oral administration as a single-agent or in combination with chemotherapy agents such as temozolomide and cisplatin (ref. 1). It is currently in clinical evaluation.
Catalog NO: CT-BMN673
Synonym: Talazoparib, MDV-3800, LT 00673
CAS NO: 1207456-01-6
Mol. Formula: C19H14F2N6O
MW: 380.4
** in vivo grade material. A single isomer (100% ee by Chiral HPLC). White Crystalline Powder (see attached picture). Bulk Stock (get discounted quote for larger size). Same day shipping.