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BIBW-2992 (Afatinib)
BIBW2992 (Afatinib) is an ATP-competitive, small molecule irreversible inhibitor for EGFR/HER2, displaying inhibitory potency against EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2, with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively; 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant.
Catalog NO: CT-BW2992
Synonym: Tovok, Afatinib
CAS NO: 850140-72-6
Mol. Formula: C24H25ClFN5O3 • 0.7H2O
MW: 498.6
** in vivo grade material, white crystalline powder (picture attached), 99.9-100% pure by achiral and chiral HPLCs + clean & impeccable 1H-NMR + a high-precision Quantitative Elemental Analysis. Same day shipping.