BI 6727 (Volasertib)

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BI 6727 (Volasertib)

BI6727 (Volasertib)is a highly potent, selective and ATP-competitive inhibitor of polo-like kinases 1 , 2 and 3 (PLK1, 2 and 3), with IC50s at 0.87, 5 and 56 nM, respectively.

Catalog NO:	CT-BI6727
Synonym:	Volasertib
CAS NO:	755038-65-4
Mol. Formula:	C₃₄H₅₀N₈O₃∙0.5H₂O
MW:	627.8

** in vivo Quality Material. The Optically Pure Source. Hemihydrate, validated by a spot-on Elemental Analysis. Buyers Beware: Partially Racemized BI6727 (with as much as10-30% non-Active Isomer) in marketplace (ref. 3).

Pricing and OrderingTechnical Data

QC & Certificates

References

NO	Size	Price	In Stock
1	5 MG	$100.00	YES
2	10 MG	$150.00	YES
3	50 MG	$420.00	YES
4	100 MG	$680.00	YES

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Solubility : In DMSO, alcohols, water with 2 eq. of acid

Storage : Store at 0°C (short term), -20°C (long term), desiccated

Purity : >99% by Achiral and Chiral HPLCs

Original QC Data : Achiral and Chiral HPLCs, ¹HNMR and Quantitative Elemental Analysis Report

Please Pick Batch NO:

BI-6727, Lot 02, Certificate of Analysis.pdf
BI-6727, Lot 02, Appearance (color).pdf

1. Rudolph, D., et al, BI 6727, a Polo-like kinase inhibitor with improved pharmacokinetic profile and broad antitumor activity, Clin Cancer Res., May 1, 2009; 15 (9), 3094-3102

2. K. Strebhardt, Nature Reviews Drug Discovery, 9, 643-660 (August 2010)

3. with the presence of wrong (Non-Active) isomer (S-Enantiomer) as much as 10-30% from those who fail to report Chiral HPLC Analysis. Only Chiral HPLC separates Active and Non-Active Isomers.

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