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Skip Navigation LinksHome > Kinase Inhibitors > RAF (Rapidly Accelerated Fibrosarcoma) > Belvarafenib (GDC-5573) (HM95573)
Belvarafenib (GDC-5573) (HM95573)
Belvarafenib (GDC5573, HM95573, RG6185) is a potent and selective Type II pan-RAF inhibitor with IC50s of 41 nM, 7 nM and 2 nM for BRAF (WT), B-RAF (V600E) and C-RAF, respectively; inhibits cell proliferation of A375 (BRAF V600E) and SK-MEL-30 (NRAS Q61K) with IC50s of 57 and 24 nM, respectively; It also inhibits the phosphorylations of MEK and ERK downstream kinases in mutant BRAF and mutant NRAS melanoma cells; shows excellent antitumor activities in mouse models xenografted with both of BRAF mutation cell lines (e.g. A375 and SK-MEL-28) and NRAS mutation cell lines.
Catalog NO: CT-BELV
Synonym: GDC-5573, HM95573, RG6185
CAS NO: 1446113-23-0
Mol. Formula: C23H16ClFN6OS • 0.4H2O
MW: 486.1
** in vivo Quality Material. 99.5% Purity, with a spot-on quantitative elemental analysis. Bulk (Grams). Prompt.