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Home > Kinase Inhibitors > EGFR Mutants > AZD9291 (Osimertinib)

AZD9291 (Osimertinib)

Osimertinib (AZD9291) is an oral, irreversible, potent and selective third generation tyrosine kinase inhibitor (TKI) targeting EGFR activating (EGFRm+) and resistance (T790M) mutations in advanced lung adenocarcinoma, while sparing wild-type EGFR. Thus, AZD9291 potently inhibits EGFR phosphorylation in EGFRm+ (e.g. PC9; <25nM) and EGFRm+/T790M (e.g. H1975; <25nM) cell lines in vitro, whilst demonstrating much less activity against wild-type EGFR lines (e.g. LoVo; >500nM).

Catalog NO:	CT-A9291
Synonym:	Osimertinib
CAS NO:	1421373-65-0
Mol. Formula:	C₂₈H₃₃N₇O₂
MW:	499.6

** in vivo Quality material. >99% Pure by HPLC. Anhydrous, validated with a spot-on high-precision Quantitative Elemental Analysis. Bulk stock (discounted price for 2G, 5G, …,). Same day shipping.

Pricing and OrderingTechnical Data

QC & Certificates

References

NO	Size	Price	In Stock	Quantity
1	50 mg	$100.00	YES
2	100 mg	$160.00	YES
3	200 mg	$250.00	YES
4	500 mg	$470.00	YES

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Solubility : Soluble in DMSO, Ethanol and Water with 2.0 eq. of HCl

Storage : Store at 0°C (short term), -20°C (long term), desiccated

Purity : >99.5% (HPLC at 214 and 254 nm)

Original QC Data : HPLC-MS, ¹HNMR, and Quantitative Elemental Analysis

Please Pick Batch NO:

AZD9291, Lot 03, Certificate of Analysis.pdf
AZD9291, Lot 03, Visual Apearance.pdf
C_K, AZD9291, Lot 03, HPLC,.pdf
C_K, AZD9291, Lot 03, NMR.pdf

1. D. Cross, et al., Mol Cancer Ther 2013;12(11 Suppl):Abstract No: A109.

2. D. Cross, et al., AZD9291, an Irreversible EGFR TKI, Overcomes T790M-Mediated Resistance to EGFR Inhibitors in Lung Cancer, Cancer Discovery, September 2014, 4; 1046

3. M. R. V. Finlay, et al., Discovery of a Potent and Selective EGFR Inhibitor (AZD9291) of Both Sensitizing and T790M Resistance Mutations That Spares the Wild Type Form of the Receptor, J. Med. Chem., 2014, 57 (20), pp 8249–8267

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