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AZD6738 (Ceralasertib)
AZD6738 (Ceralasertib) is an orally bioavailable, potent and selective inhibitor Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Kinase with a biochemical IC50 = 1 nM); induces cell death and senescence in non-small cell lung cancer (NSCLC) cell lines; potentiates the cytotoxicity of cisplatin and gemcitabine in NSCLC cell lines with intact ATM kinase signaling, and potently synergizes with cisplatin in ATM-deficient NSCLC cells. Daily administration of AZD6738 and ATR kinase inhibition for 14 consecutive days is tolerated in mice and enhances the therapeutic efficacy of cisplatin in xenograft models (refs 1, 2).
Catalog NO: CT-A6738
Synonym: Ceralasertib, M6620
CAS NO: 1352226-88-0
Mol. Formula: C20H24N6O2S∙1/2H2O
MW: 421.5
** in vivo Quality Material. 99.9%% by achiral and chiral HPLCs. A single isomer (out of 4), confirmed by Chiral HPLC (99.9%). Hemihydrate, validated by a spot-on quantitative microanalysis. Bulk. Prompt.