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AZD4635 (HTL-1071)
AZD4635 (HTL-1071) is an orally bioavailable, potent and selective A2A (Adenosine 2A) receptor antagonist, binding to human A2A receptor with a Ki value of 1.7 nM, and with > 30-fold selectivity over other adenosine receptors. High adenosine level in tumors, produced by stimulating A2A receptors, is immune suppressive, which prevents T-cells within the immune system from being activated thus reduces their ability to destroy cancer cells. Antagonizing A2A receptors can therefore promote the anti-cancer response of T-cells within the tumour microenvironment. AZD4635 is currently being evaluated as a monotherapy and in combination with other anti-PDL1 agents in patients with advanced solid cancers.
Catalog NO: CT-A4635
Synonym: HTL-1071
CAS NO: 1321514-06-0
Mol. Formula: C15H11ClFN5
MW: 315.7
** In vivo Grade Material. 99.5% Pure by HPLC. An off-white to pale-yellow powder (pic attached), recrystallized, coming with a spot-on high-precision Quantitative Microanalysis. Bulk stock! Prompt.