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AZD4320 (AZD-4320)
AZD4320 (AZD-4320) is a BH3 mimetic and highly potent dual Bcl-2/Bcl-XL inhibitor with binding affinity in low nanomolar range similar to ABT-263 (Novitoclax), but with a better therapeutic index (lower toxicities) and amenable to I. V. administration (ref 1). It rapidly induces caspase-3 (CC3) cleavage and cell death in both Bcl-2-driven (SuDHL4, GI50 <50 nM) and Bcl-XL-driven (SuDHL8, GI50 <50 nM) diffuse large B-cell lymphoma (DLBCL) cell lines; Achieves complete and sustained (>24 days) tumor regressions in a mouse RS4;11 acute lymphocytic leukemia xenograft model (20 mg/kg, i.v.) (ref 1).
Catalog NO: CT-A4320
Synonym: AZD-4320
CAS NO: 1357576-48-7
Mol. Formula: C45H48ClF3N4O7S3∙1/2H2O
MW: 954.5
** in vivo grade material. 99.9-100% by achiral and chiral HPLCs. A stereomerically pure single isomer (Clinically active isomer) with 100%ee, de (All QC Docs attached). Hemihydrate, validated by a quantitative microanalysis. Bulk stock!! Ship within 1 day.