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Home > Kinase Inhibitors > JAK1/JAK2 Selective > AZD1480

AZD1480

AZD1480 is a potent, selective and orally active ATP-competitive inhibitor of JAK1 and JAK2 with IC₅₀ of 1.3 nM and 0.26 nM, respectively. Inhibits signaling and proliferation of Jak2 V617F cell lines in vitro, demonstrates in vivo efficacy in a TEL-Jak2 model, and potently blocks Stat3 signaling and Ontogenesis in solid tumors, currently in clinical trials.

Catalog NO:	CT-A1480
Synonym:
CAS NO:	935666-88-9
Mol. Formula:	C₁₄H₁₄ClFN₈
MW:	348.8

** in vivo Quality Material. >99% pure by Achiral and Chiral HPLCs. Anhydrate, validated by a spot-on Quantitative Elemental Analysis. Bulk stock. Same day shipping.

Pricing and OrderingTechnical Data

QC & Certificates

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NO	Size	Price	In Stock	Quantity
1	5 MG	$100.00	YES
2	10 MG	$140.00	YES
3	50 MG	$360.00	YES
4	100 MG	$660.00	YES
5	200 MG	$1,000.00	YES

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Solubility : In DMSO

Storage : Store at 0 °C (short term), -20 °C (long term), desiccated

Purity : >99.5% Chem and optical purity (HPLC and Chiral HPLC)

Original QC Data : HPLC-MS, ¹HNMR, Chiral HPLC, and Quantitative Elemental Analysis

Please Pick Batch NO:

AZD1480, Current, Certificate of Analysis
C_K, AZD1480 , Lot 01, HPLC-MS.pdf
C_K, AZD1480 , Lot 01, Chiral HPLC-MS.pdf
C_K, AZD1480 , Lot 01, NMR.pdf

1. M. Hedvat, et al., The JAK2 Inhibitor AZD1480 Potently Blocks Stat3 Signaling and Oncogenesis in Solid Tumors, Cancer Cell, Vol.16 (6), 487-497, 8 Dec. 2009

2. A. Scuto, et al., The novel JAK inhibitor AZD1480 blocks STAT3 and FGFR3 signaling, resulting in suppression of human myeloma cell growth and survival, Leukemia, 2011 Mar; 25(3):538-50.

3. S. Ioannidis, et al., J. Med. Chem. 2011, 54, 262–276

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