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AZD1480 is a potent, selective and orally active ATP-competitive inhibitor of JAK1 and JAK2 with IC₅₀ of 1.3 nM and 0.26 nM, respectively. Inhibits signaling and proliferation of Jak2 V617F cell lines in vitro, demonstrates in vivo efficacy in a TEL-Jak2 model, and potently blocks Stat3 signaling and Ontogenesis in solid tumors, currently in clinical trials.
Catalog NO: CT-A1480
CAS NO: 935666-88-9
Mol. Formula: C14H14ClFN8
MW: 348.8
** in vivo Quality Material. >99% pure by Achiral and Chiral HPLCs. Anhydrate, validated by a spot-on Quantitative Elemental Analysis. Bulk stock. Same day shipping.