AZD1152 (Barasertib) - Chemietek

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Home > Kinase Inhibitors > Aurora Kinase > AZD1152 (Barasertib)

AZD1152 (Barasertib)

AZD1152 (Barasertib) is a cell-permeable, highly selective Aurora Kinase B inhibitor (>1000 fold selectivity over Aurora A) with Ki at low nM. It is a pro-drug, converted rapidly through dephosphorylation in vivo to the active ingredient AZD1152-HQPA (Our Prod. No: CT-A1152H).

Catalog NO:	CT-A1152
Synonym:	Barasertib
CAS NO:	722543-31-9
Mol. Formula:	C₂₆H₃₁FN₇O₆P
MW:	587.54

** A pale yellow crystalline solid (see attached picture), with 99% purity (HPLC at 214 and 254 nm), achieved ONLY by Chemietek. Ship within 1 day.

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NO	Size	Price	In Stock	Quantity
1	5 mg	$150.00	YES
2	25 mg	$495.00	YES

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Solubility : Soluble in DMSO and water with 1 eq. base

Storage : Store at 0 °C (short term), -20 °C (long term), desiccated

Purity : >99% (HPLC at 214 and 254 nm)

Original QC Data : HPLC-MS, ¹HNMR

Please Pick Batch NO:

Current Lot, Certificate of Analysis
AZD1152, Current Lot (Lot 00AB), Appearance (color).pdf

1. R. W. Wilkinson, et al, AZD1152, a Selective Inhibitor of Aurora B Kinase, Inhibits Human Tumor Xenograft Growth by Inducing Apoptosis, Clin. Cancer Res., 2007 Jun15; 13(12), 3682-8.

2. A. A. Mortlock, et al., Discovery, synthesis, and in vivo activity of a new class of pyrazoloquinazolines as selective inhibitors of Aurora B Kinase, J Med Chem, 2007, 50, 2213-24.

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