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Skip Navigation LinksHome > Kinase Inhibitors > JAK1 Selective > AZD-4205 (AZD4205)
AZD-4205 (AZD4205)
AZD4205 (AZD-4205) is a potent, selective and ATP-competitive inhibitor of JAK1 with a Ki of 2.8 nM, highly selective against JAK2 (IC50 =13233 nM, >4000 fold selectivity) and JAK3 (IC50 >30000 nM, >10000 fold selectivity). Demonstrates potent inhibition of p-STAT3 in a cell based assay of JAK1 activity with an IC50 of 128 nM and excellent selectivity across the kinome. Exhibits excellent pharmacokinetics, and in vitro and in vivo antitumor efficacy (refs 1, 2), and is currently in clinical evaluation.
Catalog NO: CT-A4205
Synonym: NA
CAS NO: 2091134-68-6
Mol. Formula: C25H31N9O2∙ 0.7H2O
MW: 502.2
** in vivo grade material, a beige crystalline powder (picture attached). 99.4%-100% by achiral and chiral HPLCs, with quantitative microanalysis. Bulk stock! Same Day Shipping.